diff --git a/drivers/usb/core/urb.c b/drivers/usb/core/urb.c
index 33d62d7e3929..9f3c54032556 100644
--- a/drivers/usb/core/urb.c
+++ b/drivers/usb/core/urb.c
@@ -8,6 +8,7 @@
 #include <linux/bitops.h>
 #include <linux/slab.h>
 #include <linux/log2.h>
+#include <linux/kmsan.h>
 #include <linux/usb.h>
 #include <linux/wait.h>
 #include <linux/usb/hcd.h>
@@ -426,6 +427,7 @@ int usb_submit_urb(struct urb *urb, gfp_t mem_flags)
 			URB_SETUP_MAP_SINGLE | URB_SETUP_MAP_LOCAL |
 			URB_DMA_SG_COMBINED);
 	urb->transfer_flags |= (is_out ? URB_DIR_OUT : URB_DIR_IN);
+	kmsan_handle_urb(urb, is_out);
 
 	if (xfertype != USB_ENDPOINT_XFER_CONTROL &&
 			dev->state < USB_STATE_CONFIGURED)
diff --git a/include/linux/kmsan.h b/include/linux/kmsan.h
index dac296da45c5..c473e0e21683 100644
--- a/include/linux/kmsan.h
+++ b/include/linux/kmsan.h
@@ -18,6 +18,7 @@ struct page;
 struct kmem_cache;
 struct task_struct;
 struct scatterlist;
+struct urb;
 
 #ifdef CONFIG_KMSAN
 
@@ -203,6 +204,16 @@ void kmsan_handle_dma(struct page *page, size_t offset, size_t size,
 void kmsan_handle_dma_sg(struct scatterlist *sg, int nents,
 			 enum dma_data_direction dir);
 
+/**
+ * kmsan_handle_urb() - Handle a USB data transfer.
+ * @urb:    struct urb pointer.
+ * @is_out: data transfer direction (true means output to hardware).
+ *
+ * If @is_out is true, KMSAN checks the transfer buffer of @urb. Otherwise,
+ * KMSAN initializes the transfer buffer.
+ */
+void kmsan_handle_urb(const struct urb *urb, bool is_out);
+
 #else
 
 static inline void kmsan_init_shadow(void)
@@ -295,6 +306,10 @@ static inline void kmsan_handle_dma_sg(struct scatterlist *sg, int nents,
 {
 }
 
+static inline void kmsan_handle_urb(const struct urb *urb, bool is_out)
+{
+}
+
 #endif
 
 #endif /* _LINUX_KMSAN_H */
diff --git a/mm/kmsan/hooks.c b/mm/kmsan/hooks.c
index 563c09443a37..79d7e73e2cfd 100644
--- a/mm/kmsan/hooks.c
+++ b/mm/kmsan/hooks.c
@@ -18,6 +18,7 @@
 #include <linux/scatterlist.h>
 #include <linux/slab.h>
 #include <linux/uaccess.h>
+#include <linux/usb.h>
 
 #include "../internal.h"
 #include "../slab.h"
@@ -245,6 +246,21 @@ void kmsan_copy_to_user(void __user *to, const void *from, size_t to_copy,
 }
 EXPORT_SYMBOL(kmsan_copy_to_user);
 
+/* Helper function to check an URB. */
+void kmsan_handle_urb(const struct urb *urb, bool is_out)
+{
+	if (!urb)
+		return;
+	if (is_out)
+		kmsan_internal_check_memory(urb->transfer_buffer,
+					    urb->transfer_buffer_length,
+					    /*user_addr*/ 0, REASON_SUBMIT_URB);
+	else
+		kmsan_internal_unpoison_memory(urb->transfer_buffer,
+					       urb->transfer_buffer_length,
+					       /*checked*/ false);
+}
+
 static void kmsan_handle_dma_page(const void *addr, size_t size,
 				  enum dma_data_direction dir)
 {