diff --git a/drivers/i2c/busses/i2c-i801.c b/drivers/i2c/busses/i2c-i801.c
index ed271274250b..41446f9cc52d 100644
--- a/drivers/i2c/busses/i2c-i801.c
+++ b/drivers/i2c/busses/i2c-i801.c
@@ -191,6 +191,7 @@
 #define SMBSLVSTS_HST_NTFY_STS	BIT(0)
 
 /* Host Notify Command register bits */
+#define SMBSLVCMD_SMBALERT_DISABLE	BIT(2)
 #define SMBSLVCMD_HST_NTFY_INTREN	BIT(0)
 
 #define STATUS_ERROR_FLAGS	(SMBHSTSTS_FAILED | SMBHSTSTS_BUS_ERR | \
@@ -642,12 +643,20 @@ static irqreturn_t i801_isr(int irq, void *dev_id)
 		i801_isr_byte_done(priv);
 
 	/*
-	 * Clear irq sources and report transaction result.
+	 * Clear remaining IRQ sources: Completion of last command, errors
+	 * and the SMB_ALERT signal. SMB_ALERT status is set after signal
+	 * assertion independently of the interrupt generation being blocked
+	 * or not so clear it always when the status is set.
+	 */
+	status &= SMBHSTSTS_INTR | STATUS_ERROR_FLAGS | SMBHSTSTS_SMBALERT_STS;
+	if (status)
+		outb_p(status, SMBHSTSTS(priv));
+	status &= ~SMBHSTSTS_SMBALERT_STS; /* SMB_ALERT not reported */
+	/*
+	 * Report transaction result.
 	 * ->status must be cleared before the next transaction is started.
 	 */
-	status &= SMBHSTSTS_INTR | STATUS_ERROR_FLAGS;
 	if (status) {
-		outb_p(status, SMBHSTSTS(priv));
 		priv->status = status;
 		complete(&priv->done);
 	}
@@ -975,9 +984,13 @@ static void i801_enable_host_notify(struct i2c_adapter *adapter)
 	if (!(priv->features & FEATURE_HOST_NOTIFY))
 		return;
 
-	if (!(SMBSLVCMD_HST_NTFY_INTREN & priv->original_slvcmd))
-		outb_p(SMBSLVCMD_HST_NTFY_INTREN | priv->original_slvcmd,
-		       SMBSLVCMD(priv));
+	/*
+	 * Enable host notify interrupt and block the generation of interrupt
+	 * from the SMB_ALERT signal because the driver does not support
+	 * SMBus Alert.
+	 */
+	outb_p(SMBSLVCMD_HST_NTFY_INTREN | SMBSLVCMD_SMBALERT_DISABLE |
+	       priv->original_slvcmd, SMBSLVCMD(priv));
 
 	/* clear Host Notify bit to allow a new notification */
 	outb_p(SMBSLVSTS_HST_NTFY_STS, SMBSLVSTS(priv));